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Fourteen kinds of medicinal plants were screened for determining inhibitory activities on monoamine oxidase B. The extracts of Artemisia Messer-Schmidtiana (herba), Chrysanthemum indicum (flos), Ericibe obtusifolia (radix et rhizoma) and Sophorajaponica (flos) strongly inhibited the enzyme. Among them, Chrysanthemi flos was chosen for elucidating its active principles, and some flavonoids were isolated and identified as acacetin (I), 5,7-dihydroxy chromone (II), diosmetin (III), apigenin (IV), eriodictyol (V) and luteolin (VI). IC50 were determined as following: I, 2.46; II, 0.19; III, 2.11mM, and the others showed weak inhibition.
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